Pathomorphological Studies following Experimental Acute Intoxication with the Triazole Fungicide Triticonazole in Pigs

The gross and microscopic pathomorphological changes in internal organs were investigated for evaluation of the toxic effect of the triazole fungicide triticonazole. One control and three experimental groups of pigs, treated orally via a gastic tube at doses of 0.2 g/kg (group I), 1 g/kg (group II) and 2 g/kg (group III) (0.1LD50, 0.5LD50 and LD50 respectively) were used. The pigs were euthanized 72 h after the treatment, a complete necropsy was performed and material for histological study was obtained. It was found out that the toxic effect of the triazole fungicide resulted in morphological changes in the liver (mononuclear proliferation, granular and initial toxic dystrophy), in lungs (peribronchial mononuclear proliferates), in lymph nodes (haemorrhages and lymphatic follicle activation), in pituitary gland (hyperaemia), in medulla oblongata (ballooned dystrophy of glial cells), in stomach (hyperaemia of gastric mucosa) and in kidneys (mononuclear proliferations among tubules and among nephrons).